Bioactive Small Molecules
Medchemexpress LLC LDN193189 (tetrahydrochloride) | 2310134-98-4 | 99.8% | 200 MG
LDN193189 (tetrahydrochloride) is a small-molecule inhibitor of bone morphogenetic protein (BMP) type I receptors that selectively inhibits ALK2 and ALK3 (reported IC50 ≈ 5 nM and 30 nM). It is supplied for research use only. CAS 2310134-98-4; molecular formula C25H26Cl4N6; molecular weight 552.33 g/mol.
- Selective inhibitor of BMP type I receptors.
- Potent inhibition of ALK2 and ALK3 at nanomolar concentrations.
- High reported purity (99.8%).
- Intended for research use only, not for human therapeutic use.
- Storage recommendations: sealed at 4°C; in solvent, -80°C (1 year) or -20°C (6 months).
Medchemexpress LLC Budipine | 57982-78-2 | 293.45 | 1 ML
Budipine is an anti-parkinson agent that acts as a substrate of P-glycoprotein (P-gp) and an N-methyl-d-aspartate (NMDA) antagonist. It exhibits indirect dopaminergic effects by improving dopamine release and inhibiting monoamine oxidase type B (MAO-B). This product is suitable for research related to CNS disorders, including Parkinson's disease.
- Functions as an anti-parkinson agent
- Acts as a substrate of P-glycoprotein (P-gp)
- Functions as an N-methyl-d-aspartate (NMDA) antagonist
- Exhibits indirect dopaminergic effects
- Inhibits monoamine oxidase type B (MAO-B)
- Useful for research on CNS disorders, including Parkinson's disease
Medchemexpress LLC Gkt136901 (hydrochloride) | 1254507-01-1 | 99.9% | 403.26 g/mol | C19H16Cl2N4O2 | 50 MG
GKT136901 hydrochloride is the hydrochloride salt of a selective NADPH oxidase (NOX1/4) inhibitor used in research on oxidative stress-related disease models such as diabetic nephropathy, stroke, and neurodegeneration. It is supplied as a solid with defined storage conditions and formulation recommendations for reliable experimental use.
- Selective NOX1/4 inhibition for oxidative stress research.
- High purity suitable for analytical and biological studies.
- Available in multiple small pack sizes for lab-scale experiments.
- Stable as a solid when stored sealed at 4°C.
- Soluble in DMSO for solution preparations; 10 mM recommended.
Cayman Chemical M-144, Purity: ≥98%, CAS: 2180924-19-8, 1 mg
Differs from UR-144 by having a fluorine atom on the terminal carbon of the alkyl group as well as a methyl group attached to the central indole structure; intended for research and forensic applications
Cayman Chemical SM-324405, Purity: ≥95%, CAS: 677773-91-0, 25 mg
A TLR7 agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor); selective for TLR7 over TLR8 (EC50 = >10 µM); induces IFN production in isolated human PBMCs (MEC = 10 nM); induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively); inhibits BALF eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation
Cayman Chemical CNX-1351, Purity: ≥98%, CAS: 1276105-89-5, 1 mg
A PI3Kα inhibitor (IC50 = 6.8 nM); selective for PI3Kα over PI3Kβ, -γ, and -δ (IC50s = 166, 240.3, and 3,020 nM, respectively), as well as PI3KC2A, PI3KC, PI4Kα, PI4Kβ, SPHK1, and SPHK2 (IC50s = >1 µM for all); inhibits phosphorylation of Akt in SKOV3 cells at 500 nM; inhibits the growth of SKOV3 and MCF-7 cancer cells (GI50s = 77.6 and 54.7 nM, respectively); inhibits Akt phosphorylation in mouse spleen at 100 mg/kg
Medchemexpress LLC Bim BH3 | 505070-06-4 | 99.7% | 2444.77 | 25 MG
Bim BH3 is a biologically active peptide that belongs to the pro-apoptotic Bcl-2 family of proteins. It is intended for research use only.
- Biological active peptide.
- Belongs to the pro-apoptotic Bcl-2 family of proteins.
Medchemexpress LLC NVP-ADW742 | 475488-23-4 | MFCD16038913 | 99.3% | 453.58 g/mol | C28H31N5O | 10 MG
NVP-ADW742 is a small-molecule, ATP-competitive inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) used in research on cancer signaling pathways. It has demonstrated submicromolar potency and is supplied as a high-purity research reagent.
- Selective IGF-1R inhibition with submicromolar potency.
- High purity suitable for research applications.
- Available in multiple small-scale package sizes, including 10 mg.
- Powder stable under frozen storage for long-term use.
- Applicable for in vitro and in vivo experimental studies on IGF-1R signaling.
Medchemexpress LLC Ethyl 7-bromoheptanoate | 29823-18-5 | 237.13 | 10 G
Ethyl 7-bromoheptanoate is a key intermediate and alkylating agent used in the synthesis of other active compounds, including prostaglandins and their analogues. It can also react with quinazoline derivatives containing hydroxyl groups to introduce ester group-containing side chains.
- Liquid appearance (density: 1.223±0.06 g/cm3)
- Colorless to light yellow
Cayman Chemical K6PC-5, Purity: ≥98%, CAS: 756875-51-1, 10 mg
An SPHK1 activator; activates SPHK1 in F9-12 cell lysates and isolated murine blood; induces calcium oscillations in HaCaT keratinocytes at 25 and 50 µM; inhibits oxygen-glucose deprivation/reoxygenation-induced cell death in SH-SY5Y cells at 10 µM; increases stratum corneum integrity and corneodesmosome density in a mouse model of UVA and UVB radiation-induced photoaging when applied topically at 1%
Cayman Chemical GLP-1 (1-32) (bullfrog) (trifluoroacetate salt), Purity: ≥98%, 5 mg
An endogenous incretin hormone; increases intracellular cAMP levels using HEK293 cells expressing human GLP-1R (EC50 = 0.051 nM); reduces blood glucose levels in an OGTT in fasted mice at 30 mg/kg
Medchemexpress LLC SMN-C2 | 1446311-56-3 | 98.9% | 417.50 g/mol | C24H27N5O2 | 100MG
SMN-C2 is a small-molecule modulator of SMN2 pre-mRNA splicing used in research to promote SMN2 exon inclusion. It is an analog of RG-7916 and is characterized for use in cellular and biochemical assays investigating splicing modulation and spinal muscular atrophy pathways.
- High purity suitable for research use (98.9%).
- Modulates SMN2 splicing to increase exon inclusion.
- Chemical formula C24H27N5O2; molecular weight 417.50 g/mol.
- Available in multiple milligram quantities, including 100 mg.
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (6 months).
Cayman Chemical Motolimod, Purity: ≥98%, CAS: 926927-61-9, 5 mg
A TLR8 agonist; increases the production of TNF-α and IL-12 in human PBMCs (EC50s = 140 and 120 nM, respectively), monocytes, and dendritic cells; increases cytolysis in K562 NK cell-sensitive leukemia cells at 167 and 500 nM for 48 hours; increases plasma levels of a group of human cytokines , including IL-6, IL-12p70, TNF-α, MCP-1, and MIP-1β, in NSG-HIS mice at 1.5 and 15 mg/m2; reduces tumor growth and increases tumor infiltration of monocytes and T cells in an ovarian cancer NSG-HIS mouse model
Medchemexpress LLC Calcitonin (salmon) | 47931-85-1 | 99.96% | 3431.85 | 10 MG
Calcitonin (salmon) is a calcium regulating hormone and a dual-action amylin and calcitonin receptor agonist. It stimulates bone formation and inhibits bone resorption. Oral treatment with Calcitonin (salmon) dose-dependently attenuates fasting and non-fasted hyperglycemia, reduces diabetic hyperglycemia and HbA1c levels, and improves pancreatic beta-cell function and area.
- Stimulates bone formation
- Inhibits bone resorption
- Attenuates fasting and non-fasted hyperglycemia
- Reduces diabetic hyperglycemia
- Reduces HbA1c levels
- Improves pancreatic beta-cell function
- Improves pancreatic beta-cell area
- Acts as a dual-action amylin and calcitonin receptor agonist
Medchemexpress LLC FITC-β-Amyloid (25-35) | 99.4% | 1562.81 | 5 MG
FITC-β-Amyloid (25-35) is a FITC-labeled β-Amyloid (25-35) peptide, developed for research. It is relevant to the study of neurological diseases, particularly neurodegenerative conditions like Alzheimer's Disease, and is associated with neuronal signaling and Amyloid-β research.
- Purity: 99.4%
- Molecular weight: 1562.81
- Formula: C72H103N15O20S2
- Appearance: solid
- Color: yellow to orange
- Sequence: FITC-Ahx-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met (shortened as FITC-Ahx-GSNKGAIIGLM)
- Storage: powder -80°C for 2 years or -20°C for 1 year; in solvent -80°C for 6 months or -20°C for 1 month (sealed, away from moisture).